Dr Ajinkya Bhonsle1, A/Prof JESSICA RYAN1, Mrs PAULA BUSSA1, Dr MELISSA NORTHCOTT2, Prof KEVAN POLKINGHORNE1,3, Prof A RICHARD KITCHING1,3
1Department of Nephrology, Monash Health, Clayton, Australia, 2Department of Rheumatology, Monash Health, Clayton, Australia, 3Department of Medicine, Monash University, Clayton, Australia
Biography:
Bio to come
Aim:
To define relationships between ANCA-associated vasculitis patient-reported outcome (AAV-PRO) domains and patient characteristics, other health related quality of life (HRQOL) measures, disease activity and damage.
Background:
The AAV-PRO questionnaire assesses AAV-specific PROs but has not been evaluated in an Australasian context.
Methods:
AAV patients attending a vasculitis clinic were assessed at an outpatient visit using the AAV-PRO (six domains, each scoring 0-100, higher is worse), BVAS (activity), VDI (damage), SF-36, and patient and physician global health assessments (PtGA/PhGA).
Results:
Eighty-eight patients participated (86% kidney involvement, 39% active disease). Systemic symptoms (SS, 36.0) and concerns about the future (CAF, 32.9) were the highest (worst) scoring domains. Physical function (PF) was lowest (22.9). Scores were similar between males and females. AAV-PRO domains were negatively correlated with SF-36 (-0.264 to -0.686, all p<0.05, Spearman’s Rho) and PtGA/PhGA (-0.361 to -0.648, p<0.01), except organ specific symptoms (OSS/PhGA: -0.150). PR3-AAV patients had higher treatment side effects (TSE, 34.4 vs 23.2, p=0.01, t-test) and CAF (40.1 vs 28.3, p=0.02) scores than MPO-AAV. Patients >65 years old had higher TSE scores (32.6 vs 23.8, p=0.03). Only PF scores were higher in active disease (29.8 vs 18.5, p=0.05) and only PF correlated (weakly) with BVAS (0.273, p=0.01). Patients diagnosed >5 years ago had higher OSS (33.5 vs 23.3, p=0.03), TSE (33.5 vs 23.3, p=0.01), and CAF (38.5 vs 28.0, p=0.03). Those with a VDI >3 (indicating significant chronic damage) reported a higher TSE (36.5 vs 24.2, p=0.02) and CAF (43.3 vs 28.5, p=0.01).
Conclusions:
AAV-PRO scores correlate well with other HRQOL measures, but not with activity or BVAS, highlighting the potential value of the AAV-PRO in holistic clinical care.
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