ADEQUACY AND SAFETY OF RENAL BIOPSIES IN PREGNANCY – A CASE-CONTROL STUDY
Dr SOO YING ONG3, JUN MAI3, BEATA ZAHOROWSKA3, DANIELA POTTER1,2,3, RENUKA SHANMUGALINGAM1,2,3, STEPHEN T SPICER1,3, ANGELA MAKRIS1,2,3
1South West Clinical School, University of New South Wales, Sydney, Australia, 2School Of Medicine, Western Sydney University, Sydney, Australia, 3Department of Renal Medicine, Liverpool Hospital, Liverpool, Australia
Aim: Compare adequacy and safety of renal biopsies performed during pregnancy with biopsies performed in women who are not pregnant.
Background: Percutaneous renal biopsy is an invasive procedure and is associated with well-described risks. Renal biopsies are avoided during pregnancy due to the perception of increased rate of complications as a result of pregnancy-related physiological and mechanical changes. There is limited data on the adequacy and safety of performing renal biopsies in pregnancy.
Methods: A single-centre retrospective case-control study was undertaken comparing women who underwent a renal biopsy during pregnancy (including within 1 week of delivery) to women that underwent a renal biopsy at other times. Cases were identified from a renal biopsy database (2012-2023). Controls were chosen based on age, body mass index (BMI) and year at time of biopsy. Demographic data were collected from the electronic medical record. The primary outcome was complication rate. Secondary outcomes included biopsy adequacy and pregnancy outcomes. SPSS was used for analysis.
Results: 40 women were included (20 control and 20 pregnancy group) and there were no group differences in age (mean=31.4+6.2yrs), BMI (median=27.6(IQR24.0-33.4), serum creatinine (69(IQR52-99) µmol/L or biopsy year. There was no difference in the rate of complications (p=1.0). There was no difference in biopsy inadequacy (less then 10 glomeruli or inadequate for diagnosis): 20% pregnancy vs 10% control group (p=0.7). BMI best predicted biopsy inadequacy (p=0.014). Most biopsies were performed in the first trimester (35%, n=7).
Conclusion: There was no difference in the complication or adequacy rate for biopsies performed during pregnancy. Pregnancy should not be a precluding factor in women presenting with significant renal manifestation warranting a renal biopsy.
Biography:
Dr. Soo Ying Ong is a Resident Medical Officer at Liverpool Hospital, New South Wales, Australia. She graduated with Honours Degree in Bachelor of Medicine and Bachelor of Surgery from Monash University. She shares an exceptional passion and enthusiasm in Renal Medicine, with a strong interest to pursue her career as an aspiring nephrologist.