NO DIFFERENCE IN FOLLOW-UP ESTIMATED GLOMERULAR FILTRATION RATE BETWEEN HYPERTENSIVE AND MATCHED NONHYPERTENSIVE KIDNEY DONORS
Jeehyun Heo1, Eun Hye Yang1, Soon Bae Kim 1 1Division of Nephrology, University of Ulsan college of Medicine, Asan Medical Center, Seoul, Republic of Korea
Abstract
Background: According to current guidelines, kidney donor candidates with controlled hypertension using 1 or 2 antihypertensive drugs may be considered as donor. However, this recommendation is based on the study that antihypertensive drug was initiated in mainly “after donor registration” and this may be white-coat hypertension because of donationrelated
anxiety. We compared the follow-up eGFR between kidney donors with preexisting hypertension and matched nonhypertensive donors.
Methods: This single-center retrospective study classified 97 living hypertensive donors previously
receiving antihypertensive drugs into two groups: 1 drug group (61 donors) and 2 drugs group (36 donors). We compared the follow-up eGFR between each donor previously receiving antihypertensive drugs and three matched nonhypertensive donors in terms of
age, sex, and follow-up duration.
Results: At a mean (range) of 51 months (12–214) in the 1 drug group, and 54 months (12–175) in the 2 drugs group after donation, there was no significant difference in follow-up eGFR between hypertensive donors previously receiving antihypertensive drugs and matched controls in each group and in total donors. There was no difference in the incidence of the
patients with follow-up eGFR < 45 mL/min/m2 in each group and their matched controls.
Multiple linear regression analysis showed that baseline eGFR was the only independent
predictor for the final follow-up eGFR in the total donors.
Conclusion: Our results support the current guidelines that donor candidates with controlled hypertension using 1 or 2 antihypertensive drugs may be considered as donors, and may increase the strength of this recommendation.
Biography
I am a fellow in nephrology of Asan medical center in Seoul.