REMDESIVIR IN COVID-19 PATIENTS WITH KIDNEY DISEASE: A STUDY ON THE RENAL FUNCTION AND OUTCOMES
CRYSTAL FAYE Lagura1 1Philippine Society of Nephrology, davao, Davao City, Philippines2philippine college of physicians, davao, Davao City, Philippines
Abstract
Aim. This study aims to determine the effect of Remdesivir on renal function and outcomes among COVID19 patients with kidney disease.
Background. The COVID-19 pandemic has high mortality rates and Remdesivir, an antiviral, showed to shorten time to recovery. However, individuals with kidney disease were not included in clinical trials, thus when emergency use authorization was granted, it was recommended to avoid use in patients with eGFR <30mL/min “unless benefit outweighs the risk”. Methods. This retrospective study included the following: >18 years old, RT-PCR confirmed COVID19 infection treated with Remdesivir and who were confirmed to have kidney disease.
Results. There were 106 patients included; the mean age was 62.25±13.9 years old, 53% were male. The majority had acute kidney injury (70.7%) while the rest had chronic kidney disease and 25% underwent dialysis. Most of them were classified as severe (66%) and critical (25%) COVID infection.
To determine effects on renal function laboratory parameters were determined at baseline and after completion of treatment. There was an overall significant improvement in eGFR (<0.01), albuminuria (0.013) and in acid-base balance (0.003) and odds ratio showed that none of the demographic, clinical and laboratory profile significantly increased the chance of death in terms of overall clinical outcome. Conclusion. Use of Remdesivir in patients with kidney disease was not associated with renal function deterioration. Contrary to concerns there was rather an overall significant improvement in eGFR, degree of albuminuria and acid-base balance after treatment regardless of their disease severity and its use in patients on hemodialysis have not shown any detrimental impact on mortality.
Biography
Dr. Crystal Faye G. Lagura is an Internist – nephrologist who graduated from Southern Philippines Medical Center in the year 2022. She is practicing adult disease specialist since 2018 and currently a practicing nephrologist in her hometown of Don Carlos and nearby municipalities in the province of Bukidnon, as a student, she graduated with honors and always embody excellence in her clinical practice. A kindhearted individual that includes serving the least fortunate and a well-rounded clinician that utilizes available resources in the community she also has interest in pursuing further training in critical care, interventional and transplant nephrology.