INCIDENCE OF CMV AND BK VIREMIA IN KIDNEY TRANSPLANTATIONS IN CENTRAL AUSTRALIA
Jessie-anne Mascaro1, SAJAN THOMAS2, SHAHID ULLAH3, CHERIAN SAJIV2 1St Vincents Hospital Melbourne, Melbourne, Victoria, Australia2Alice Springs Hospital, Alice Springs, Norther Territory, Australia3Flinders Univeristy, Adelaide, South Australia, Australia
Abstract
Aim:
To identify the incidence of Cytomegalovirus (CMV) and BK viremia in Kidney Transplantations in Central Australia.
Background
CMV and BK are opportunistic infections post renal transplantation which can cause graft dysfunction and increase rate of graft loss. This study explores the incidence of CMV and BK viremia in two eras (pre and post 2015), induction agents and their association with viremia, and also reviews if ethnicity is a risk factor for infection in First Nation Australians.
Methods
We completed a retrospective single-centred cohort study of patients aged over 18 in Central Australia who had undergone a renal transplantation between January 1980 to December 2021. Patients were categorised into two groups pre-2015 and post-2015, associating with the type of induction agent at the time of renal transplantation, Anti-thymocyte globulin (ATG) or non-ATG based regimen. The primary endpoint was incidence of CMV or BK viremia from the time of transplantation.
Results
We analysed 101 people in Central Australia who underwent a renal transplantation. The incidence of CMV viremia was significantly higher in the post-2015 era (OR, 7.45; p=0.02). Ethnicity was also identified as an independent risk factor for CMV viremia in the First Nation Australian population (OR, 3.276; p=0.032). The rate of BK viremia was higher in the ATG standard induction group and First Nation Australian group however it was not statistically significant.
Conclusions
This study demonstrates a statistically significant increased risk of CMV viremia in the post-2015 era in the First Nation Australians. There was no significant association of CMV and BK viremia with the type of induction agent. Further research is needed to identify ways to prevent CMV infection in high-risk groups.
Biography
Bio to come