EFFECT OF PROBIOTICS SUPPLEMENTATION ON INFLAMMATION AND OXIDATIVE STRESS IN ASIAN DIABETIC KIDNEY DISEASE PATIENTS: A META ANALYSIS OF RANDOMIZED CONTROLLED TRIAL
Herleni Kartika1,2,3, Zulkhair Ali1,2,3, Eddy Yuristo2,3, Ian Effendi1,2,3, Novadian Suhaimi1,2,3, Suprapti Slamet1,2,3, Deddy Primadona1,2,3, Syahpri Putra Wangsa1,2,3, Kgs M Yusuf Arief Akbar1,2,3, Elfiani Elfiani1,2,3, Rery Tri Ferri Yuniarti1,2,3, Novandra Abdillah Pratama1,2,3, Edy Nur Rachman1,2,3, Chairil Mr1,2,3, 1Division of Nephrology and Hypertension, Mohammad Hoesin General Hospital, Palembang, South Sumatera, Indonesia2Department of Internal Medicine, Mohammad Hoesin General Hospital, Palembang, South Sumatera, Indonesia3Faculty of Medicine, University of Sriwijaya, Palembang, South Sumatera, Indonesia
Abstract
Aim. This meta-analysis aimed to evaluate the effect of probiotic supplementation on C-reactive protein (CRP) as marker of inflammation and malondialdehyde (MDA) as marker of oxidative stress in Asian DKD patients.
Background. Diabetic kidney disease (DKD) is a progressive complication of diabetes characterized by chronic inflammation and increased oxidative stress, which can contribute to disease progression and cardiovascular complications. Probiotics, which are live microorganisms that confer health benefits when consumed in adequate amounts, have been proposed as a potential therapeutic option to improve inflammation and decrease oxidative stress in DKD patients.
Method. A systematic literature search was conducted in PubMed and Embase databases up to April 2023. RCTs that looked at the effect of probiotics on CRP and MDA in Asian DKD patients were included. To assess the quality of the included studies, the Newcastle Ottawa Scale (NOS) tool was used. Efficacy of probiotics was assessed by weighted mean difference (WMD) and Confidence Intervals (CIs). Data were analyzed using RevMan 5.4 software.
Result. Three RCTs involving 180 CKD patients were included in the analysis. The results showed that probiotics supplementation for 12 months significantly reduced hsCRP (standardized mean difference [SMD] = -2,04. 95% confidence interval [CI] –3.12 to -0.96, p <0.001) and lessened MDA level (SMD = -0.67, 95% CI -0.87 to -0.48, P = <0.001) in patients with DKD. Conclusion. The findings suggest that probiotic supplementation may have a beneficial effect on inflammation and oxidative stress in Asian DKD patients, as evidenced by reductions in CRP and MDA levels. Keywords. Probiotics, Inflammation, Oxidative Stress, Diabetic Kidney Disease
Biography
I am a Trainee Nephrologist, Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Mohammad Hoesin General Hospital, Sriwijaya University, Palembang, South Sumatera, Indonesia