RESOLVING INFLAMMATION AND SUPPRESSING FIBROSIS IN THE VASCULAR COMPLICATIONS OF DIABETES

EP Brennan¹, M. Mohan2, M.de Gaetano¹, M. Barry³,P. Guiry⁴, K Jandeleit-Dahm², M. Cooper², P. Kantharidis², Catherine Godson¹

¹Diabetes Complications Research Centre, Conway Institute & School of Medicine, ²Department of Diabetes, Central Clinical School, Monash University, Clayton, Vic, Australia, ³St Vincent’s University Hospital, ⁴Centre for Synthesis and Chemical Biology, University College Dublin, Ireland

Under physiologic conditions the duration and amplitude of inflammatory responses is tightly controlled in response to the generation of endogenous mediators including lipids. The failure to resolve inflammatory responses results in chronic, insidious pathologies typified by vascular complications of diabetes such as accelerated atherosclerosis, diabetic kidney disease and compromised regeneration and repair. We have investigated the potential of lipid mediators and synthetic mimetics to promote the resolution of inflammation in  experimental models including diabetic kidney disease. We report on the therapeutic potential of several novel compounds.