Dr Rajesh Jhorawat1, Dr Mahendra Kumar Jangid1, Dr Manish Chaturvedy1, Dr Santosh Kumar Maurya1, Dr Nitin Kumar Bajpai1
1All India Institute Of Medical Sciences, Jodhpur, Jodhpur, India
Background: PEW, sarcopenia, and frailty are commonly seen in advancing CKD and have been linked with adverse outcomes in various studies. Psoas Muscle index (PMI) has been shown to be effective in predicting sarcopenia in CKD patients. This study was conducted to see the relationship between PEW and PMI.
Methods: This was a cross-sectional study and included diagnosed cases of CKD who were attending Nephrology outpatient care. The protein-energy wasting (PEW) was diagnosed by the criteria proposed by The International Society of Renal Nutrition and Metabolism (ISRNM). Psoas Muscle Index (PMI) was calculated on a CT scan.
Results: A total of 90 patients were included. The mean age of the study population was 51.81±14.61 yrs., 68.9% were male, mean BMI was 19.85±3.20 Kg/m2. Male had significantly more PMI compared to females (4.512±1.929 vs. 3.229± 1.231, p=<0.001). Age had strong relationship with PMI (r=-0.375, 95% CI -0.539 to -0.180, p=<0.001). In nutritional parameters, BMI (r=0.276, 95%CI 0.730 to 0.457, p=0.008), SGA (r=-0.216, 95% CI -0.404 to -0.008, p=0.041) and handgrip (r= 0.311, 95%CI 0.109 to 0.485, p=0.003) had statistically significant correlation with PMI. In regression analysis, handgrip strength and PEW were independently associated with PMI (beta coefficient 0.282, 95% CI 0.003 to 0.245, p=0.042 and beta coefficient 0.461, 95%CI 1.152 to 2.763, p<0.001, respectively). The prevalence of PEW was 75.55% in our study. PMI was significantly low in PEW patients compared to those who had not (3.523±1.194 vs. 5.936±2.260, p<0.001).
Conclusion: PMI is an important indicator of sarcopenia, and it has an independent and significant correlation with protein-energy wasting (PEW) in CKD patients in our study.
Biography:
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