Dr SEONJU KIM1, Dr YOOHWAN KIM1, Dr JAEYUN LEE1, Dr MINSEON CHEONG1, Dr SOONBAE KIM1
1Asan Medical Center, Songpa-gu, South Korea
She received her medical degree from Kosin College of Medicine, and finished her residency training at Asan Medical Center (AMC) which is Korea’s leading hospital. She is currently a clinical fellow in the Department of Nephrology at AMC. Her clinical practice and research focuses mainly on health promotion, and medication adherence.
Background: The most important complication of kidney biopsy is bleeding, and it is unclear whether desmopressin is effective in preventing it.
Aim: This study was conducted to compare post-biopsy bleeding with or without desmopressin prescription prior to percutaneous kidney biopsy.
Methods: In this single-centered, retrospective, and observational study, 3,018 adult patients who underwent kidney biopsy between January 1, 2003 and March 31, 2019 at our institute were recruited. Of these, 776 patients received desmopressin. To compare the differences in major bleeding events between patients administered and not administered with desmopressin, propensity score matching was performed.
Results: Before propensity score (PS) matching, it was observed that patients in the desmopressin group were significantly older (p < 0.001) and had a higher blood pressure (p < 0.001), higher serum creatinine (p < 0.001), lower hemoglobin levels (p < 0.001), and lower platelet counts (p = 0.001) than those in the no-desmopressin group. Furthermore, the incidence of renal artery embolization was not significantly different between the two groups (p = 0.077);however, blood transfusions occurred significantly more frequently in the desmopressin group (p < 0.001). A comparison of the two groups after PS matching did not reveal any differences in the incidence of renal artery embolization (p = 0.341), blood transfusion (p = 0.579), and total major bleeding events (p = 0.442). Furthermore, there was no difference in the incidence of perinephric hematoma on computed tomography or ultrasound (p = 0.120).
Conclusions: We do not recommend desmopressin administration before kidney biopsy.
Biography:
Dr. SEONJU KIM is an nephrologist in South Korea, who believes that patient care should be a physician’s first priority.