Miss Ling Lin1, Dr Yangqin Chen1, Dr Dongwan Han1, Dr Andrew Yang2,3, Dr Amanda Y Wang3,4,5, Dr Wenjie Qi1
1Department of Infectious Disease,Beijing Friendship Hospital,Capital Medical University, Beijing, China, 2Department of General and Acute Care Medicine,Royal North Shore Hospital, Sydney, Australia, 3Concord Clinical School,the University of Sydney, Sydney, Australia, 4Division of the Renal and Metabolic,George Institute for Global Health,The University of New South Wales, Sydney, Australia, 5Department of Renal Medicine,Concord Repatriation General Hospital, Concord, Australia
Aim: To perform a systematic review assessing the clinical manifestations and outcomes of cardiorenal syndrome or the presence of both cardiac and renal complications in the 2019 coronavirus disease (COVID-19) patients.
Background:Cardiorenal syndrome can occur in COVID-19 patients, precipitated by arrhythmias, acute cardiac injury, and acute kidney injury. Limited data is available when evaluating the outcomes of COVID-19 patients with cardiorenal syndrome.
Methods:All relevant studies about cardiorenal syndrome or both cardiac and renal complications in COVID-19 patients were retrieved on PUBMED, MEDLINE, and EMBASE from 1 Dec 2019 to 20 Feb 2022.
Results:Our search identified 15 studies including 637 patients with a diagnosis of cardiorenal syndrome or evidence of both cardiac and renal complications followingSARS-CoV-2 infection. They were male predominant (66.2%, 422/637), with a mean age of 58 years old. Cardiac complications included myocardial injury (13 studies), heart failure (7 studies), arrhythmias (5 studies), or myocarditis and cardiomyopathy (2 studies). Renal complications manifested as acute kidney injury with or without oliguria. Patients with cardiorenal injury were often associated with significantly elevated levels of inflammatory markers (C-reactive protein, procalcitonin, interleukin-6). Patients with a diagnosis of cardiorenal syndrome or evidence of both cardiac and renal complications had more severe disease and poorer prognosis (9 studies).
Conclusions:The presence of either cardiorenal syndrome or concurrent cardiac and renal complications had a significant impact on the severity of the disease and the mortality rate among patients with COVID-19 infection. Therefore, careful assessment and management of potential cardiac and renal complications in patients with COVID-19 infection are important to improve their outcomes.
Biography:
Bio to come